Consider for just a moment the setbacks you've experienced in your life so far. Viewed with a present day perspective, which of those setbacks ended up having a significant upside?
When nodes on my vocal cords hastened the end of my years making a living as a singing guitarist, I was very unhappy as well as unsure how I'd support myself. Since college graduation, being a working musician had been my entire professional identity. Though I don't recall how long I felt sorry for myself, I do know that setback felt insurmountable at the time. Had someone challenged me to find an upside, I'm certain I would have thought them deranged.
Nowadays, most of my magical moments with music occur when I'm playing guitar and not singing. And when I lose myself playing, sometimes I'm able to draw a line from my setback to my present joy. Had I continued for all the ensuing years just accompanying my singing, my present day ability as a guitarist would not be as advanced. It's unlikely I'd ever have taken the time to learn how to read music and playing solo jazz guitar - however rudimentary - would have remained a dream.
Now, if I could turn back the clock, would I choose to not have that setback occur despite the subsequent upside? Oh boy - you go first.